GNW-Adhoc: New Phase 3 data with aprocitentan to be presented at the European Society of Hypertension Annual Meeting 202

^Allschwil, Switzerland - June 23, 2023
Idorsia Ltd (SIX: IDIA) today announced that further data for aprocitentan,
Idorsia's investigational dual endothelin receptor antagonist evaluating the
treatment of patients with resistant hypertension, will be presented as an oral
presentation by Prof. Markus Schlaich, MD, at the European Society of
Hypertension's 32(nd) European Meeting of Hypertension and Cardiovascular
Protection, taking place in Milan, Italy, 23-26, 2023.
The presentation is scheduled for Monday, June 26 (14:05 - 14:15 CEST) in Yellow
Hall 1, as part of the "Resistant and Uncontrolled Hypertension 2" session,
entitled "Effects of the dual endothelin antagonist aprocitentan on ambulatory
blood pressure indices in patients with resistant hypertension - results from
the PRECISION study". The presentation focuses on the effects on relevant
indices of ambulatory BP measurements (ABPM), including post-hoc analysis of
patients at high risk of cardiovascular events based on night-time BP values.
The abstract can be found in the meeting program
(https://esh2023.eu/programme/).
In May 2022, Idorsia announced positive top-line results of the Phase 3
PRECISION study with aprocitentan for the treatment of patients with resistant
hypertension. Detailed results were published in The Lancet and presented as a
Late-Breaking Science presentation during the American Heart Association (AHA)
Scientific Sessions in November 2022. More details and commentary can be found
in the dedicated press release (https://www.idorsia.com/investors/news-and-
events/media-release-details?newsId=2869821) and an investor webcast
(https://www.idorsia.com/investors/news-and-events/Apro-session-AHA-
2022) featuring Prof. Markus Schlaich, an investigator in PRECISION. A new drug
application (NDA) for aprocitentan was filed with the US FDA in December 2022,
and the market authorisation application (MAA) was submitted to the EMA at the
end January 2023.
Notes to the editor
About Prof. Markus Schlaich, MD
Markus Schlaich is a nephrologist and a European Society of Hypertension (ESH)
accredited hypertension specialist. He is a Fellow of the American Heart
Association (FAHA), the European Society of Cardiology (FESC), and the
International Society of Hypertension (ISHF). He served as an Executive
Committee of the ISH from 2018-2020 and is currently on the Management Board of
the global ISH May Measurement Month campaign. Markus is President of
Hypertension Australia and a Trustee of the Foundation for High Blood Pressure
Research.
Markus has a strong background in clinical research with a focus on the
pathophysiology of hypertension, involvement of the kidneys, and hypertension
mediated organ damage. He has a specific interest in treatment modalities
targeting the sympathetic nervous system and other relevant pathways such as the
endothelin system to improve BP control and thereby outcomes for patients with
difficult to control hypertension. For his work he received the Björn Folkow
Award from the European Society of Hypertension (ESH) and the Arthur C. Corcoran
Award from the AHA Hypertension Council, both in 2021. He has authored more than
450 articles in peer-reviewed journals and serves on the Editorial Board of
Hypertension and Journal of Hypertension. Prof. Schlaich serves as a consultant
to Idorsia.
About Idorsia
Idorsia Ltd is reaching out for more - We have more ideas, we see more
opportunities and we want to help more patients. In order to achieve this, we
will develop Idorsia into a leading biopharmaceutical company, with a strong
scientific core.
Headquartered near Basel, Switzerland - a European biotech-hub - Idorsia is
specialized in the discovery, development and commercialization of small
molecules to transform the horizon of therapeutic options. Idorsia has a 20-year
heritage of drug discovery, a broad portfolio of innovative drugs in the
pipeline, an experienced team of professionals covering all disciplines from
bench to bedside, and commercial operations in Europe, Japan, and the US - the
ideal constellation for bringing innovative medicines to patients.
Idorsia was listed on the SIX Swiss Exchange (ticker symbol: IDIA) in June 2017
and has over 1,300 highly qualified specialists dedicated to realizing our
ambitious targets.
For further information, please contact
Andrew C. Weiss
Senior Vice President, Head of Investor Relations & Corporate Communications
Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, CH-4123 Allschwil
+41 58 844 10 10
investor.relations@idorsia.com
media.relations@idorsia.com
www.idorsia.com (http://www.idorsia.com)
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estimated or expected.
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Quelle: dpa-AFX